Glider
Captain
The US Navy in the Pacific felt that the 50 cal was quite effective aginst surface ships up to the size of and including DDs. There were instances of patrol craft and small coasters being disabled by AC armed with 50 cals.
I would certainly believe that wooden patrol boats and small coasters would be at risk but would be suprised if anything bigger would be at risk.
The USN were quite keen to introduce the 20mm, all F6-F5 Hellcats were capable of being equipped with 2 x 20 and 4 x 0.50.
Postwar I believe the USN were quick to introduce the 20mm whilst the USAAF stuck with the 0.50.