I do wonder what the frontal area between a Hornet nacelle and a Mustang nose was as far as if there was some similarities. It seems that the spinner size was similar, though the Mustang probably had a bit more frontal area ultimately due to having to accomodate a pilot behind it.
Also a case of what-if here, but what if the Spitfire was designed or redesigned to use a cowling with a larger spinner and was even more streamlined? The P-38K Lightning did something similar, though it never entered mass production (USAAF didn't really want it, were happy with the P-38J/L, as well as the P-47D and P-51B/C/D/K models, and worried about disrupting P-38 production).
And, what if the Hornet used updraft intakes instead of the downdraught ones? There's tradeoffs for both. The downdraft ones reduced frontal area (supercharger intakes were wing mounted), but the updraft ones probably could've made more power (straight shot into the carb/supercharger).