Getting back off the Whirlwind for a bit we have the earlier mentioned Gloster F.9/37
RR Peregrine engines with beard radiators.
and the infamous near vaporware Bristol Taurus engines.
With the Peregrines the speed was around 330mph at 15,000ft.
After the first radial engine plane crashed and was rebuilt with a later model Taurus engine the performance dropped by 25-30mph and no Taurus engine ever made that kind of of power at 15,000ft again.
More photos here
The Gloster F.9/37 (also known as the Gloster G.39) was designed to meet specification F.9/37 which called for a twin-engine, two-seat day and night fighter. The aircraft that emegered from the Design Team, led by W.G. Carter, was a twin-engine monoplane bearing more than a passing resemblance...
ww2aircraft.net
You have a 386 sq ft wing which could be cut down.
changing to Merlins may require quite a bit of modification. Not impossible but using heavier engines that far forward harder than doing it further back.
Plane was also under 12,000lbs gross as built so heavier armament, heavier engines and more fuel also needs work.
Early P-38s went around 15,000lb with 300 US gallons of fuel and only 200rpg for the four .50 cal guns and 150rounds for the single 20mm.
Granted no Turbos in our British twin engine fighter but..............Going to Merlins and 3-4 20mm guns is going to run up the weight.