The 25-30 kg gun and it's ammo can be installed on most of fighters from second half of the 1930s without much of problems (even on the small Bf 109, I-16 or MB.152), not the case with a 100 kg gun and it's ammo.
The M4 - M10 37mm gun was used on the P-38 (early versions), P-39, and P-63.
The P-38 was similar in size to the Me-110.
The P-39 was similar in size to the Me-109.
The P-63 was similar in size to the Fw-190.
The Germans problems were a reliance on types designed to carry 7.92mm guns. They had to adapt them for the heavier weapons needed to complete the bomber interception mission.
The same problem was run into by the P-36 and P-40; designed for .30cal and adapted to .50cal weapons.
The P-38, P-39, and P-63 were designed to intercept bombers and carried heavy cannon from the start.