I repeat - then how did Messerschmitt do it for the Bf.109/110? Ju.210 was 974lbs, while DB.601 was 1,300+ lbs.
Messerschmitt did a lot for the 109. The 109 with the DB 601 didn't fly until Dec 1937 not counting the two race planes.
Mock up was inspected May 11th 1934. The favored engine at the time was the BMW 116 and an installation mock up arrived in July 1934. First metal was cut in Dec of 1934.
The Jumo 210 was now favored over the BMW 116 but the Jumo wasn't ready either.
May of 1935 sees the Bf 109V1 fly with the Kestrel. The 109V1 was repowered after a crash and both it and the V2 flew within a day or two of each other in Dec 1935.
Now I am sure that Messerschmitt had heard of the DB 600 engine. Especially since the Bf 110V1 and several more 110V series planes flew with starting in May of 1936. The 110 didn't switch to the Jumo 210 until 3-4 (?) planes with DB 600s were built due to problems both with the DB 600 engine itself and with the delivery of sufficient numbers of DB 600 engines.
The 110 was never
intended to use the Jumo 210 so the question of how they fit the DB 600 into the 110 doesn't apply.
Because the 109 was designed with an eye towards larger engines from the first place. The DB600, which is a ~1230 lb (dry) engine, was already running on the bench by 1932 and was ready for aircraft by 1935.
The DB 600 was far from "ready for aircraft by 1935" and it wasn't really ready for much of 1936. It was flown in those years but while the Germans considered suitable for bombers in the early years it was not considered suitable for fighters. How fast it could be sorted out was questionable, and lead to a lot of planes using Jumo 210 and Jumo 211 engines. DB couldn't reach production deadlines either.
Now for all of the engine swappers here, it could be done, but the change over for many planes was a more than just comparing the weight of the "dry" engine.
The 109E (with four machine guns) had a take-off weight 450kg more than the Jumo 210 powered aircraft. The fuselage structure as well as the undercarriage were both beefed up.
In addition to all the visible changes. Which did include going to the 400 liter tank (with little or no protection)
Messerschmitt may have been dreaming of a DB powered version of the 109 in 1935-36 but the DB 600-601 engine was not a viable product at that time and Messerschmitt was turning out scores if not hundreds of Jumo powered 109s while DB was getting their act together.
How much of a total redesign was the Spitfire XII vs. the Spitfire V, apart from obvious engine and cowling change, as well as installation of a bigger cooling system?
Doesn't look like a Spitfire V rudder to me
They got lucky with the Spitfire.
I get taken to task when ever I say that but and the "luck" was accompanied for by a lot long hours and sweat and hard thinking.
However the Spitfire happened to have enough wing and a long enough fuselage and other attributes of size that some of the needed modifications weren't too disruptive.
Want to try to imagine a Buffalo with enough rudder and fin to control a 1600-1700hp engine on it's short, pudgy fuselage

The Spitfire's largish wing kept take-off and landing speeds more manageable as the weight and power increased than planes with about 3/4s the wing size.