Continuing:
4. The ideal location and method of injection is direct injection to the cylinder i.e. diesel. Now, as the technology to do that with gasoline in automobile engines didn't exist until about a decade ago, for WWII, it gets very grey. Is it better to cool the incoming air by injecting before the supercharger? Just after the supercharger/before the intercooler? Just after the intercooler?
If you have a small engine (relatively), that you want as much boost as possible to make it competitive, you want the gasoline injected as early as possible.
If you have an air cooled engine, that you need as much cooling as possible in the cylinders, do as late as possible so it is still evaporating
5. became separate list
6. Already answered.
7. You're describing exactly what Allison build with the V-1710-127: Almost 3k hp and BSFC of 0.405 lb/hp.
You just need a plane like the P-63 to be able to install it into.
8. Double edged sword: You don't necessarily want your airframe to be locked into a specific engine in case it fails. Whirlwind being point in case: Without the Peregrine, Westland didn't have an engine to power its fighter.
Conversely, you don't want your engine locked into a specific airframe for the same reason. If the Fw190A had failed, BMW might not have had a substantial market for its radial.
But overall, there was a lot of cooperation between airframe and engine manufacturers. And a lot of angst when thing changed between the mockup and the initial delivery.
9. Rolls-Royce is actually a pretty good example. The Griffon Mk. 1 was buried when it became apparent that fuel had moved on to 100 octane and beyond. So, a whole new engine was designed in late '39 and it finally began to overshadow the Merlin in '44.
6 more months and Vulture might have succeeded; but RAF didn't have 6 months. (Would have help if Manchester wasn't overweight and really needed 2,500 hp engines, not 1,750 hp ones.)
P&W R-2800 is about the same timeline.
10. Triptane
Not fuel additives, but Goring Ha-Ha gas (Nitrous Oxide), Water Injection and Nitromethane are all good, short duration, power boosters.