Two Do 335s on the same mission?
Actually, I'd nominate the He 274, though it didn't make production since it used the He 177, but replaced the unreliable Siamese twin DB 610 engines with a more reliable engine setup. Of course, the DB 603 didn't make it for long, either, but the DB 605 would have slipped right in, and there was nothing wrong with the He 177 airframe, so the He 274 SHOULD have been a good one.