In many cases the speed listed in most published specifications is for a "normal" gross weight. From Joe Baugher's site under B-17F
"34,000 pounds empty, 40,437 pounds loaded, 56,500 pounds maximum. "
Which makes nonsense out of the speed listings as the planes were normally flown.
B-17s and B-24s over Europe did NOT run for home. Since part of their defence was the firepower of the large formation/s. stringing the formation out with each plane running at it's best speed was not going to happen. The faster you go the more fuel you burn per mile. Getting away from German fighters only to force land in North West France, Belgium, Holland or the English channel wasn't such a good plan either.