If you allow 10MPH for fit finish and cleanliness, 10 MPH for reduction in cooling drag and 10MPH for lower drag aerofoils that gives you the 30MPH difference, it takes a lot of horsepower.To be honest, I do wonder how much the Meredith effect is fact vs myth. Obviously, there's something to it, as with laminar flow wings. But I don't think that theory 100% paid off in terms of real world results. It's like comparing the P-51 with the Spitfire. When powered by similar engines, the P-51 was a good 30 mph or so faster on top end than the Spitfire, and it took the Griffon engined Mk 14 at least 300-400 more bhp to reach the same speeds.
Overall, I think that P-51 was just a cleaner airframe than the Spitfire. The fit and finish above all on the Mustang was seemingly miles ahead of a lot of Spitfires. You have to remember that it seemed that Spitfires didn't go fully to flush riveting for all external panels until sometime in 1943. The Mustang did this basically all along going back to the NA-73X prototype.
I do believe that the laminar flow wing and Meredith radiator done well helped, but they weren't the sole magic bullets. I'd bet that a lot of why the Spiteful was so fast was just lessons learned from designing the Spitfire and gains in manufacturing and aero made since the mid 1930s.
That's why sort of my "dream" fighter would have the best attributes of the Mustang and the Spitfire. IMO, we got pretty close with the XP-51F and G, and sort of approached that with the P-51H. Or maybe if the P-51B/C/D/K was able to keep the weight to NA-73X or P-51/Mustang I levels.