No doubt, but was Darwin worse than Malta or the forward bases in the Western Desert?
Malta was around 1,800 miles from England, 945 miles from Alexandria, maybe a little more to Gibraltar.
Darwin was 8,000+ miles from England, 2,000 miles from Sydney. It was much more remote. It took a lot longer to get there or to get things there.
In both cases resupply was fraught, but communication and coordination was extra difficult with the added distance.
Anyway there seem to have been mistakes made with the Spitfires shipped over from the UK. The glycol wasn't drained from the coolants system and no stabilizer was added for the long ship journey, resulting in serious corrosion. Gun heaters were either disconnected or not installed. Both of these issues were discovered after they caused serious problems in combat. There was some other issue with the propeller pitch control or something but I forgot the details. Suffice to say they were plagued with issues - which isn't unusual for combat aircraft staring up operations in a new Theater, but they didn't really have enough time to shake them out before they were thrown into the mix with the Japanese raids.
So personally, between the serious maintenance problems, the bad 20mm ammunition and the incorrect Tactics (despite having very understandable reasons for them) were all against the RAAF. I do think Darwin was an outlier.
However the Spitfire more generally didn't do spectacularly well in the Pacific and CBI, and I think it is because it just wasn't ideal for the Theater. It was designed for the defense of England and in general, for Northern Europe, where it excelled. With some tweaking in terms of kit and tactics it did well in Southern Europe as well. Further afield, it was perhaps too specialized. Not enough range / endurance and didn't like operating in filthy miserable conditions like you would have in Darwin or say, New Guinea.