What strikes me the most reading the posts in this thread is the attitude of the USAF compared to the RAF, it must have been frustrating seeing P47-P51's flying to Germany when your own plane after 4 years of war could still barely cross the channel.
The USAAF's attitude was that the bombers didn't need escorts at all until the Luftwaffe started destroying the bombers in large numbers in the latter half of 1943. Even after this the 8th AF commanders were unconvinced, and would have continued raids into Germany had it not been for (mainly) the weather preventing "precision" bombing.
Note that at this time the P-47 was not much better than the Spitfire in terms of escorting bombers - neither could escort the bombers to Germany.
The RAF's attitude was that it was necessary, but not possible. They discovered this the hard way early in the war, and switched, predominately, to night bombing.
This attitude did not change, even after the P-51 (not the P-38 or P-47) showed it was possible. But for the RAF it was a moot point, as by 1944 their night bombing raids were as accurate as the 8th AF daylight "precision" raids, thanks to technological bombing aids (H2S, Oboe, Gee-H).
It must be noted that the Spitfire was always intended as a home defence fighter, hence it remained with small amount of internal fuel. The Typhoon had longer range then the Spitfire, but failed because of lack of altitude performance.
So, no, I doubt that the RAF ever felt any frustration at not having a domestic long range fighter (the RAF did field the Mustang III and IV, their versions of the P-51B and D).
I also doubt that the attitude of the USAAF had anything to do with the range of the P-51B before it actually flew in combat. It was a function of fuel carried, the engine and the efficiency of the airframe, none of these parameters ever being defined by the USAAF.