The Flight test reports will specify the deterioration of cruise speeds in level flight and in some cases reduction of climb speeds with various loadings, But -
Each external load represents two detriments to maximum performance. First is Parasite Drag which affects top speeds in level flight. Second is Weight which affects both Climb performance as well as increasing Induced Drag.
Very simplicly:
Total Drag = Parasite Drag + Form Drag + Induced Drag.
If the aircraft is capable of flying in Mach numbers > .5M, then the equation looks more like this. Total Drag=(Parasite Drag+Form Drag)*Cf+Induced Drag. Cf= Compressibility factor ranging from 1.0 in incompressible flow near .3M to 1.2-1.3 for regime near Compressible drag rise to 1.3 to 1.5 as shock waves form on classical WWII airfoils. The propeller also experiences compressible drag rise as tip speeds from combined rotational velocity and forward velocity and must be added to the equation.
Rate of Climb= (Thrust*Velocity-Drag*Velocity)/Weight for steady state climb angle.
So the external load impinges on Drag and Weight values.
If you are trying to 'Game' this realistically - good luck finding accurate drag values as they not only vary as a function of Reynolds number, but also as a function of angle of attack, variable density of the air. Ditto propeller thrust which varies for velocity, Hp, and prop efficiency.
Next challenge is to find the 'real' Parasite Drag numbers as analyzed by the manufacturer - most of which are not available - then plug in the chart values for RN, re-calculate the Velocity as a function of density and Mean Aerodynamic Chord.
In many cases, given enough flight test data which reports flight conditions of Gross Weight during speed runs at specific altitudes, assume the plotted HP is to manufacturer's specs (occasionally correct but usually within 2-3%), assume the contribution of exhaust velocity to Thrust is in the range of 0.1 to 0.13 of the Thrust Hp as calculated above, then and only then do you have the data to develop (Parasite Drag CDo)*Cf.
The Sea Level values are best place to start because the top speeds are usually below .50 to .55M and the Compressibility factor Cf is close to 1.0. Also the prop tips aren't usually M>=.98M.
Obviously the above assumptions are NOT correct for Reno Unlimited Racers. At 500mph for a Mustang at 5,000 feet above Sea Level - the P-51 is zipping along at ~ .67M. Even with 3500 Hp it has just about reached its absolute limits because a.) prop is well into supersonic drag conditions, b.) the Compressibility Factor for a stock Mustang at .67M is about 1.4, and c.) approaching Q load dynamic pressure limit. The wing and the prop are really the only variables left to play with to squeeze a few more knots as the Merlin has tapped out in context of squeezing HP further (IMO).