The LRDG was formed specifically to carry out deep penetration, covert reconnaissance patrols and intelligence missions from behind Italian lines, although they sometimes engaged in combat operations. Because the LRDG were experts in desert navigation they were sometimes assigned to guide other units, including the Special Air Service and secret agents across the desert. During the Desert Campaign between December 1940 and April 1943, the vehicles of the LRDG operated constantly behind the Axis lines, missing a total of only 15 days during the entire period. Possibly their most notable offensive action was during Operation Caravan, an attack on the town of Barce and its associated airfield, on the night of 13 September 1942. However, their most vital role was the 'Road Watch', during which they clandestinely monitored traffic on the main road from Tripoli to Benghazi, transmitting the intelligence to the British Army Headquarters.
With the surrender of the Axis forces in Tunisia in May 1943, the LRDG changed roles and moved operations to the eastern Mediterranean, carrying out missions in the Greek islands, Italy and the Balkans. After the end of the war in Europe, the leaders of the LRDG made a request to the War Office for the unit to be transferred to the Far East to conduct operations against the Japanese Empire. The request was declined and the LRDG was disbanded in August 1945.
The Axis also had LRDG special forces, with the italians in particular having some impressively equipped units. The crews of A.S.37 put forth very favorable judgments on these vehicles; their four wheel drive and large diameter wheels prevented them from becoming easily bogged down. The A.S.37 principal defect lay in a silhouette too high and thus too visible.