I think the P-38 would have been better off with one or two more .50 cal in the nose rather than the 20MM cannon. A 15MM cannon like the BF-109F had might have been a good compromise, and hence the value of up-scaling the .50 cal. I do not recall ever reading where a P-38 pilot decided to shoot just his 20MM cannon because it was more effective, although most of the airplanes were equipped with separate machine gun and cannon firing buttons. I recall reading of one unit that used one button for both the .50 cal and 20MM, used the extra button for push to talk radio, and used the former PTT "horn button" in the center of the wheel to jettison the drop tanks rather than the previous location where it was hard to find when under duress.