I'm thinking of something along these lines:
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http://i.pbase.com/o4/30/511730/1/64601170.GoVGFvIY.webConvair.jpg
I think the aerodynamics would have been possible in the development phase. The big problem is the engines. Possibly the most powerful/reliable engines in production at the time would be the R-2800. Not sure if they are enough to power such a large aircraft.
The only aspect I wouldn't think could be applied is the nacelles. They were developed from experience which wasn't available in the period when the design needs to be commenced.
Merlins aren't strong enough. Maybe Griffons - 2 stage ones for better high altitude work, maybe turbocharged (I know not historically done). Alternative engines I would push for altitude versions of the Sabre, possibly turbocharged, and would encourage Allison to develop the V-3420. So you have 3 possibilities there, in case one or more fails.
I would drop the pointed nose, and opt for a more traditional flight deck. I would tend to keep the aircraft unarmed, or just limit the armament to a rear firing 20mm cannon, controlled remotely.