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Indeed. The most well known genetic mutation is getting cancer.
 
Perhaps those people did not kill them because they were unaware of the snake's presence, bitten, and therefore dead?

No, the snake evolved over time. The rattle became smaller and smaller over time until it no longer had one.

Take the Santa Catalina rattlesnake for example.

After reading up on it, is believed that mutation/evolution occurred because of hunting purposes. Making it quieter. I originally thought it was for survival.

Beautiful snake really…

 
A nice example of a 'mutation' that is phenotypic can be seen in this petunia. This is actually not a normal 'mutation', but caused by a transposon aka a jumping gene. There are pieces of DNA that can 'transpose' themselves in the genome. In this case it 'jumped' right into one of the genes for color in this flower and basically in random cells, which gives this flower it's pattern of red on white. Each flower would have it's own pattern as the transposition is basically random. I used to study the genetic regulation of the forming of flowers in Petunia in my thesis 20 years ago.

 

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