Okay, let's put a single stage R-2800 into a P-43 in 1940 and rip out the turbo. That should give us a low level hotrod to defeat the enemy everywhere, although maybe only the Russians would take it.
Probably - the CoG is messed up due to now much heavier nose and no turbo behing the pilot.
OTOH - design the P-51 around the 1-stage R-2800 from the get go...