If the DB 601N stays as-is, runs the same RPM, pushes the same boost (without pre-detonation happening - this might be the kicker) etc, the resulting power should be as it was - no decrease.
Upping the boost further, to ~1.40 ata, will see the increase of another 5%? That is more than 1200 HP for TO.
Again - on a same engine type, the lower octane fuel and greater boost are usually mutually exclusive things. I'd strongly suggest reduction of compression ratio, preferably to 6.5:1, if not to the Merlin's value (6:1). Yes, some power will be lost for same boost and RPM, but there should be peace of mind for B4 operation.
601N was running at extra 200 rpm at rated altitude vs. the 601A, so we indeed should be getting better power at altitude.
Going with increased CR is fine and dandy if engine can take it. Otherwise, staying conservative with CR is probably less troublesome approach.
Time for the experts to chime in