Postwar, the appearance of torquemeters and fuel flowmeters allowed more accurate control of mixture. For instance, the 1962 C-131 flight manual says, "as automatic carburetor operation will not permit the attainment of maximum precision in the control of fuel flow and mixture strength, and since the AUTO LEAN mixture position is set to smooth engine operation rather than fuel economy, some method of manually leaning the cruise mixture is desirable."
At high power (1200+ hp from each R-2800) the procedure is to manually adjust the mixture lever to attain the fuel flow specified in the chart. At lower power you use the torquemeter. Slowly move the mixture lever, searching for the point of peak torque. That's "best power" mixture. Now lean the mixture until the torque reduces by the amount in the chart.
This method for attaining best economy was not restricted to transports and bombers. The Skyraider had a torquemeter (no flowmeter though) and you used a similar process to find best economy cruise.
Getting back to the C-131, that plane was a military version of the Convair 240 short haul airliner, one of which infamously crashed in 1977 with the band Lynyrd Skynyrd aboard after exhausting its fuel. It has been speculated that excessively rich fuel metering was a factor, though the investigation couldn't pin down anything definite. But if the plane had torquemeters and flowmeters like its military sibling, such a malfunction should have been evident to the pilots.