The top turret or ball turret could cover the same area, but they'd probably be looking for fighters closer to the center of their coverage area, and a fighter slipping in from the side might not be seen in time.
In the case of the fight of the B-25 Tondelayo, the crew chief had the radio operator spy on the top turret gunner's legs as he fired at oncoming Zeros and then look out the opposite waist window and shout out a head's up when a threat was coming close. (They had expended 1,200 rounds of .30 ammunition through the two waist guns which would have been their usual posts during an attack...in later model B-25s they would have been .50)
Jack Murphy said he had a Zero pull up between his B-25 and another one flying in close formation. The Zero close enough that he could see the Japanese pilot swiveling his head back and forth to make sure that either turret gunnercould not shoot for fear of hitting the other B-25 as well. Jack said he looked like "a mean s.o.b.".
Murphy turned his turret away as a ruse but kept his eyes glued on this Zero, which immediately tried to climb out from between the two bombers. Jack Murphy gave the unfortunate Zero a short burst in the cockpit and the Zero went down.