Not really, wing twist and profile changes (both of what the Spit had) can actually reduce induced drag, if done right of course.
Negative. Wing twist adds a small increment to Induced drag - no mater how well or poorly it is done
Remember the twist makes the tips more perpendicular to the air flow, ie a lower angle of attack. This in itself will reduce drag, at the cost of lower lift in level flight.
Actually what 'twist' accomplishes is ONLY to reduce the angle of attack for the outboard span where ailerons are located and provide for stalling Inboard first so that roll control is maintained as the inboard (less twisted) airfoil stalls first
This also helps stalling, since the tips have a lower stall speed than the inner wing, again because of that varying angle of attack.
The greater the angle of attack the higher the stall speed (with the usual caveat, or weasel words, "all other things being equal").
As the inboard section of the twisted wing stalls, the wings lose the greater part of its Lift and effectively Stalls even when the tips maintain some lift distribution and attached flow for aileron authority.
The Mustang had wing twist too, but the Spit combined that with a profile change. Those 2 factors gave the Spit its gentle stall, combined with the shape and thinness this maintained low induced drag even with such a low wing loading.
Yes the Mustang also had twist for the same reasons - maximum aileron authority while the rest of the wing was going to hell in a handbasket..
The price paid was the complexity, so you didn't get something for nothing.
Now the 109's slats, were not your modern ones, all hydraulically and computer controlled. They were on or off, often quite abruptly too.They did mean a very simple wing with a good landing stall speed at the price of control issues when one or more slats came into operation in higher speed maneuvers (even in landing with cross winds and so on ...brr). There was also a drag issues due to gaps (etc) in the leading edges and of course maintenance, dust, snow, ice and mud clogging up the slats were not a lot of fun.
You pays your money and you takes your choice.