You may want to look at the British twins again. They were very good at what the did do but that was NOT daylight air to air combat against high performance fighters.
Hence why I didn't refer to any British twin that actually reached operational status. (though I mentioned the Mosquito would have a tough time due to G-limits and maneuverability)
I rather doubt that the F.9/37 had less drag than the P-47 what with it's twin engines and bigger wing. Usefulness of the Defiant seems to be based of an estimate of an unflown proposal. Installation of the Merlin XX was not all that it could be in practice??
I'm not thinking of something exceptional, but something closer to an indiginous British P-40 possibly with a bit more room for growth in internal tankage. (the P-40 itself was much better in the long-range role than the Spitfire or Hurricane ... just not good enough to manage the extreme ranges heavy Bombers were pushing over Europe)
So perhaps not potential to be a deep penetration fighter capable of staying with the bombers on their longest routes, but a hell of a lot closer than anything else the British had in production.
And the F.9/37 was more in terms of potential growth ... it might not have worked out, but given the dimensions and design of the airframe (and provisions for a second crewman), it seems a fair bet that it had lots of potential for expanded internal fuel tankage (unlike the Whirlwind) while being a more practical day fighter than the Mosquito (G-limits among other things).
Modified Mosquitos MIGHT have made sense too, but between maneuverability and stress limits of the airframe, it seems less likely.
We have been over this a number of times. F4U starts out carrying much less fuel inside than a P-47, has little or no advantage in drag and has to work it's engine harder even at 18-24,000 ft in high speed cruise than the P-47 does.
Faster level flight, acceleration, and climb rates at low/mid altitudes than early P-47s (prior to boost limits being raised), lower weight, greater roll and turn rates, and I'm assuming use of the wing tanks. (and replacement with self-sealing tanks on later models rather than deletion)
Once again, an escort fighter needs to be able to fight. Not just show up. F2A-3 began to come out of the factory in Jan 1941, about the time the First Bf 109Fs were showing up. F2As would have been in trouble against 109Es, against 109Fs in the summer of 1941 they would have been just so many more targets. Granted they may have saved bombers by having the 109Fs use up their ammunition shooting them down but sacrificial lambs is not a good long term strategy.
True, and by the time the F2A-3 arrived, better aircraft were on the horizon anyway ... and drop-tank eqipped F4Fs probably would have fared better. (barring hypotheticals like an F2A fitted with the 2-stage R-1830 of the Wildcat)
Even so, with equal pilots, the F2A-3 may have fared better than the Hurricane at least. (similar speed and climb, but more maneuverable -especially at high speeds)
The 1939/1940 argument is a bit limited here since allied bombing wasn't really significant until after that point, so the really early fighters with the necessary range are only really relevant when there was no serious need for them. (one could argue for the Germans being better off with F2As or especially P-40s during the battle of brittian, but drop-tank equipped Bf-109Es would have been perfectly suited to the short ranges involved there ... albeit P-40s, Buffalos, and Wildcats ... and P-39s for that matter all made better fighter-bombers due to range/fuel load compared to contemporary 109s)
A stop gap has to actually work, at least somewhat. P-40s needed Spitfires flying top cover in order to survive in North Africa. If you escorts need escorts that doesn't leave you much range for the bombing mission. And BTW "2x synchronized .50s is a bit weak" it was more than a bit weak. The US .50 probably took to synchronizing the worst of any gun that was successfully synchronized. British tests report a rate of fire of under 500rpm. One wing gun could fire almost 90% of the rounds that cowl guns could. Also you have to figure out which P-40 you are using. The D/E/F used engines that shifted the prop shaft upwards 6in.
Like the Buffalo and F4F, I'm speaking mostly very early war (before the P-38, P47, or F4U could be ready) so it'd be P-40B/C/Tomahawk. (the C is actually a bit too late for the early-war requirement) But the allusion to the P-40 D/E wing did imply later use as well, so those factors are valid from that standpoint.
As to the armament, nose guns have concentration of fire, lack of convergence zone limits, and effectiveness round per round over wing mounting. (both the British and Americans seemed to actively ignore/decry this advantage when the Soviets, Germans, and Finns seemed to recognize it much more -including Soviets removing the P-39 wing guns and Finns noting the nose mounted .50 brownings of the F2A were more efficient than the wings in spite of the much lower RoF -and opted for 4x nose mounted .50s in their indiginous fighter development -while the P-51 had its pair of nose guns deleted -or removed in the field on the A-36- ... as did the F4F)
Nose guns are pretty definitively more affected, but realistically (looking at historical US/British doctrine/tendencies) this argument is largely compromised if for no other reason than due to preference over utility.
That whole argument may be superfluous anyway if the P-40's wing was ill suited for fuel in/around the gun bays. (just keep the wing guns ... or even consider adding the nose guns to later models if possible -again ... doctrine/preference seems to nix that idea regardless of technical feasibility)
It's also worth noting that compared to the 8 gun Spitfire and Hurricane, 2 500~600 RPM .50 BMGs still managed better than half the firepower of 8x .303 brownings. (and the 4x .30-06 brownings + 2x .50s had more firepower than the 8 gun british fighters) At very least using these metrics for firepower
The WWII Fighter Gun Debate: Gun Tables
(in fact roughly 130% the firepower of an 8-gun spit/hurricane)
There's also one other thing relating to the P-51, especially relevant when comparing the P-40 to Spitfire and 109. Not only was it a 'lucky' design to fit the long range category, but was just an exceptional all around performer lucky enough to NOT have the enemy challenge it with a similarly advanced short-range interceptor. (As the spitfire and 109 were to the P-40) Unless you count the jets but those came too later and too few to matter.