"The designers at Reggiane took the airframe of a P-43"
That would be a little tough. The P-43 didn't fly until about year after the Reggiane 2000. They may have had a good look at a P-35 airframe though.
The cost may be because the the Republic aircraft used more pieces. Part of it is simply weight. Part of it ( for the Italians) is the lack of proper mass production tooling ( few jigs and fixtures and more hand work). Total fly away cost of the P-47 includes the P&W R-2800, the turbo, all the ducting, the fancy landing gear and the guns. Eight guns cost twice as much as 4 and 33% more than 6. And you need the firing solenoids, ammo boxes, gun mounts, gun heaters. etc.
Part of it may be basic design features. For the P-47 see:
Design Analysis of the P-47 Thunderbolt