I agree completely, my point was that it is a sensible choice to put a turbo behind the pilot in a P-47, putting a turbo in the back of a car or bike may work "just" but would be very difficult to drive.I know from some of your previous posts that you are an experienced bike racer. I also know that you know the difference between single stage and two stage superchargers.
I have no first hand knowledge of how a two stage system with a mechanical stage suffers from "lag" in it's turbo auxiliary stage. I would suspect that the throttle response is better than a turbo alone. I have read that the P-38 may have suffered and that there were two methods to get around it. The discredited high rpm, low boost cruise which used more fuel, wore out the engines quicker, over cooled the intake mixture and kept the large GE turbos at low rpm (and a GE turbo is absolutely huge compared to a modern car or bike turbo). or the preferred low rpm, high boost method of cruise, the turbo is spinning thousands of RPM higher, the intake mixture is not puddling in the manifolds and there is a fair amount of boost available to increase power (torque) as the the throttle is opened (or prop control moved?) to accelerate the engine/props.
You also have how the propeller acts as it goes from cruise to high speed. I believe (but could very well be wrong) that the prop is in coarse pitch (or close to it) to give the most speed for a low rpm. when the throttle is opened up and rpm increased the prop should go to a finer pitch as the engine gains rpm and then as the power increases and the speed increase the prop should go back to coarse pitch as high speed is approached?
Most of the people trying to compare modern cars/bikes to WW II engines seem to forget the aircraft engines were operating in rather thin air insead of the "soup" that most cars and bikes operate in. The AIrcraft engine at 20,000ft is only getting about 53% as much "air" (by weight) per cubic ft as the engine at sea level.