Too bad there isn't a Ta-152 that is flyable. Then we could see it in action. But all we have right now are the records of it, and since it was rarely used in combat, it doesn't give a lot to go on.
The Ta-152 did shoot down a Tempest in a turning battle, but the Tempest had very poor turning abilities at low altitude. Even the Spitfire could outturn it.
As for speed, the Bearcat has the record for fastest Piston fighter at 528.33 mph.
I don't know if the Ta-152 could beat that speed in combat. With boost it could go 470 miles per hour, an impressive speed.
The P-51-H and P-47M Mustang also had speeds comparable to the Ta-152.
I think on this forum I have heard it said that the Ta-152 had such a high ceiling that all Allied fighters couldn't withstand it and would become sitting ducks, but that still is just speculation.
Even if in theory the Ta-152 could swoop down on bombers and blast them to pieces then zoom up again to high range, while the Allied fighters could barely get a shot at it, in reality often fighters with poor performance can still make suprisingly good kills.
Take the Brewster Buffalo by the Finns. It did magnificently against the Russians. Now maybe if the Russians were flying Ta-52's the outcome would have been different. It could have been slaughtered then, like it almost was against the Zero's at Midway.