Shortround6
Major General
Not really new. B - C - D - E - F. Until the end (K), the adjustments were always small. The biggest change was E -> F, not a priority for performance but in more production-efficiency. (Blueprints for F are dated from mid-1940)
I am agreeing with Tomo. The B-D were one generation, differences were minor and often just a change in equipement.
I am not sure if you could turn a D into an E, to would take quite a bit of work and parts.
But an E is basically a D with a new engine, new radiator installation (and oil cooler) and larger fuel tank.
The F has a lot more changes to the basic airframe and no, it wasn't just for production reasons. An early F was 20-30mph faster than a late model E when using the same engine. Later Fs did get higher powered engines but the change from a 350mph airplane to a 390mph airplane was NOT due to the new engine alone. This is the major break between the 1935 109 and the 1944-45 109s. from the F on there was little or no aerodynamic refinement and performance increases came from fitting increasing more powerful engines. Which unfortunately for the Germans and fortunately for the rest of the world, often had teething troubles that lasted for months and prevent full use from being made of the hoped for power increase.
late 109s were a mad scramble to get something into the air and aerodynamic refinement went out the window. The wing bulges over the tires on the K series may have negated much of the gain from the auxiliary wheel well doors for example.