Greg, please go over the time line for the P-38. There are two different issues with fuel at different times.
The early US fuel had little or no aromatics, this was in 1940 or so, If you want 100/125 or 100/130 you have to use aromatics. At least if you want to make fuel on a large scale.
When the Americans started to use the 20% (max it could be less) fuel there were all sorts of problems, including dissolving rubber parts in the fuel systems and self sealing tank liners, Jetting may very well have been a problem but the other problems were bigger. ALL of the problems were eventually solved. This is in regards to the early 100/130 fuel.
Early 100/130 fuel was limited to 3.0ccs of lead per US gallon and while there could be 20% aromatics in the fuel the types of aromatics may have been restricted. Use of aromatics is also restricted by the standard of BTUs per pound of fuel (18,700?) and most or all of the aromatics are lower than that so if you use too much of the aromatics in the blend you have somewhat lower than requirement heat value per pound.
At some point in 1942 (early?) they decide that if they use 4.0 cc of lead per US gallon they can get a lot more 100/130 fuel from the same amount of base stocks so that is approved (after testing to see about lead fouling) and in late 1942 or early 1943 they decide they need a lot more 100/130 fuel and the way to do that is to allow 4.6cc of lead per gallon and allow more of the heavy aromatics but still not exceeding about 20% total. everybody knew that this "new" 100/130 might cause problems and the engine makers began testing it with the engines at the beginning of 1943. Allison found they did have troubles under certain conditions and started working on a new intake manifold in the spring of 1943. It was being fitted to engines and P-38s in either November or December of 1943 but since it takes weeks to get a P-38 From California to Europe all the planes in theater had the old manifolds.
As Shortround notes the US started producing and using avgas with high aromatic content in 1942, however his chronology is slightly askew:
4 cc of tetraethly lead was allowed in November 1941 (Others sources say December)
125 PN was called for in May 1942. (Other sources note that it was mandated after July 1)
130 PN was required in December 1942.
This from AAF Historical Study No 65 "Aviation Gasoline Production and Control" which I believe I have posted previously but I am attaching here.
The US began introducing aromatics into their fuels produced in the l USA in May 1942 with the production of the aromatic cumene (Isopropyl benzol). In addition all 14 of the catalytic crackers existing in the US were converted to the production of Avgas.
To quote Sam Heron from his book Development of Aviation Fuels
"In lieu of suitable straight run gasolines, aromatics and the sensitive cat cracked gasolines (which largely owed their sensitive and rich mixture properties to aromatics) became desirable material for making Grade 100/130 in maximum quantity."
An excellent book for those who are interested in the actual production of Avgas (and every thing else related to petroleum):
Amazon product ASIN 1410221954
I purchased this book about 5 years ago but it has since been digitized and is available via Google Books for free.
A History of the Petroleum Administration for War, 1941-1945
This book says the following about cumene and its importance:
The above figure from the same book illustrates the importance of the aromatic cumene and cat cracking in enabling the production of massive quantities of high octane avgas.