You are mistaken, the rear mounted Merlin supercharger required an additional 90 degrees of intake airflow direction change compared to the flank mounted superchargers.
I wrote, "Additionally, the later DB superchargers were quite efficient and, it has to be remembered that losses in a 2-stage supercharger are multiplied." I state that, I do not imply they were more efficient, later DB superchargers were quite efficient and multi-stage supercharging does suffer from multiplication of efficiency losses.
On the point of which superchargers were the more efficient, I make no claims because that is a very specific point. However, data in Calum Douglas' superb co-authored book Turbo/Supercharger Compressors and Turbines (TSCT) does have a lot of detail on this and I recommend it to anyone who is interested.
As regards charge-cooling, the various high supercharged German engines, including DB 605 L and DB 603 L, used ADI or Intercoolers as they saw fit, although their actual use of the intercooling option was generally very late in the War.
Eng