For an HE round the 6 pounder could have been built around the 75mm case/shell as was done for tanks. Not a rebore, as sometimes stated, but a new barrel and the chamber made for the French/US case. So now you are firing a 3 inch semi automatic gun at a destroyer. Despite claims of a ROF at 3s seconds per round period film demonstrates other claims of just under one round per second are more representative. Now add a proximity fuse and you get a plausible bomber downing capability. The down side is that you have a large twin engined aeroplane with a heavy load (gun/loader) at the mercy of escorting single engined fighter and a larger target for the bombers defence guns.
The 75mm swapped velocity of flight for weight of shell with the end result being little difference in the forces involved at the firing end. As said above, what the 3" rocket projectile brought was flexibility, even if the accuracy was appalling.
BTW just to mention. The B25 75mm gun was hand loaded which is hard enough on the ground never mind in a small space moving in 3 dimensions with huge gravity issues. Worse than a tank. Reloading 20mm cannon drums in a night fighter Beaufighter was bad enough.