Zipper, such planes with four engines would be so far removed from the 2 engine planes that were built that no meaningful comparison can be made. It would be much more than adding 15 ft or so to each wing and sticking an extra engine nacelle in the new space. Avro got away with it with the Lancaster, in part because they were replacing two 1800hp engines with four 1200-1300hp engines and already had a rather long fuselage.
The B-18 and Martin 146 were already using just about the largest and most powerful engines they could get at the time. What the engine makers were promising for the future (2-4 years ahead) may have been different. B-17 used a wing that was about twice the area of the wing on the Martin 146.