It's true that the O/100 was impressive for it's time, indeed, but compare the B-19's size, lift capabilities and range to that of postwar strategic bombers.
Yup, but that's not what you stated. The O/100 was the grandfather of the strategic bomber. It was used by the RNAS for strategic bombing attacks, as was its successor the HP O/400 by the RAF, and then there was the big V/1500, which was designed specifically to fly to Berlin and back. Surely these qualify as the grandfather of strategic bombers well before the XB-19, especially since the former two were actually used in the role in combat.
Let's also not forget the Zeppelin attacks against Britain, but also the RNAS attacks against German airship facilities in 1914, which qualify as the first strategic air raids.