The French tried the extra engine in the fuselage trick just before the war (?) and the Germans tried later in the war with the Hs 130E.
A DB605T powering the central supercharger feeding the DB603 engines in each wing.
There were 3 experimental Do 217Ps with the same basic powerplant.
Basically recon machines as there was no room for bombs (or very many) once they stuffed the 3rd engine, central supercharger, intercool, 3rd engine radiator and needed fuel into the existing (?) fuselage.
A lot of countries issued specifications for bombers (and fighters) that were beyond the state of the art. These specifications helped push the state of the art but most (all?) of the extreme specifications failed. In 1939 the US Army was asking for a twin engine medium bomber that could carry a 2,000lb bomb load 2000 miles. What they got were the B-25 and B-26 which were lucky to fly 2000 miles with no bombs and a bomb bay full of fuel.
Anybody trying for a bomber that could fly at 40,000ft carrying a 20,000lb bomb in 1940 needed more years of development in aerodynamics, structures and propulsion to pull it off.
North American tried a medium bomber and flew it in April 1942.
Twin turbo R-2800s (P-47 engines) but the service ceiling was only 34,800ft and the normal bomb load was 2000lb.
You are not going to make 40,000ft using the airfoils and flaps of 1938/40 carrying the load you want.
The US post War B-50s were not just B-29s with new engines. They also used a new aluminum alloy for the wing skins and a restress structure.
The KB-50J tankers got to just under 40,000 without guns and with a J-47 5200lb thrust turbo jet under each wing but that was around 1950?
Now there is a huge gap between the Lancaster as modified to carry the big bombs and the what the thinking was in 1939/40. Where they might have wound up in 1944/45 could be quite a bit better than the Lancaster but it wasn't going to be what they were talking about in 1940.