As has been pointed out the Spitfire was faster than the 109 at certain altitudes. The 109 had thin wings and a small structure which was very fast that small structure and thin wings had no room for larger weapons or even thicker tyres. All designers trade speed for maneuverability, if you dont you end up with a plane that needs perfect conditions to land, lands and takes off at high speed and kills a lot of its own pilots, if an aeroplane cannot maneuver how does it get in a position to shoot?No, what I was trying to communicate is that the -109 had all the best traits, at least as history has taught us and any plane that traded speed for maneuverability like the Mustang and Spitfire got a less powerful weapon.
History tells me that the Spitfire was a match for the 109 throughout the war especially the BoB and Malta while the P51 swept it from the skies over Germany in 1943/44