Of the Italian 18 cyl engines, seems to me that Piaggio's types were the best - Fiat's A.80 seems like too much of complication to gte to 1100 HP, and Alfa's 135 never powered an in-service A/C due to excessive vibrations.
The Italian 18 cyl engines all seemed to be from the same class room. They seemed to be too light. This
seems to have restricted the rpm limits (?)
Engine.................................................Displacement.............................Weight............................RPM
R-2800-5.......................................2804 cu.in./ 45.9 L...............................2270lb..........................2600rpm
Alfa 135.........................................2940 cu.in./ 48.2 L...............................2094lb..........................2400rpm
Fiat A80.........................................2789 cu.in./ 45.7 L...............................1625lb..........................2200rpm
Fiat A82.........................................2873 cu.in./ 47.1 L...............................1910lb..........................2400rpm
Piaggio P.XII................................3232 cu.in./ 53.0 L...............................1874lb..........................2100rpm
Piaggio P.XXII.............................3691 cu.in./ 60.5 L...............................2094lb..........................2200rpm
Compare the R-2800 to the Piaggio XII, the Piaggio is 15% greater displacement but the R-2800 runs almost 24% faster.
If you can't use boost (high octane fuel) you have to use displacement
and RPM. The Italians could not use high rpm.
Issotta-Fraschini ASSO XI
I have no idea how they got the mixture from the carbs to the end cylinders. The W-18s were worse. Middle bank of cylinders were fed by carbs on the outside banks and the passages went through the valve compartments.
Between the bearings and the intake passages there was room for improvement.