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I think I get it having worked in Flight Planning for years I was preaching to the ones who don't get it , that is is why I always question cruising speed because almost no flight plan ever had a C47 or 46 any where near there max cruise speed .On a lot of passenger/cargo planes the useful payload is NOT for a "fully' fueled and oiled aircraft. depending on the stage length ( particular route flown) a plane could be filled with less than full tanks and allowed more passengers or cargo, exact same plane could then fly the next stage of the flight with a different fuel/cargo combination. Even DC-3s had what were referred to as auxiliary tanks. On modern jets the "useful" load can vary by tens of thousand's of pounds depending on fuel load.
I doubt the Ju 252 would have reached mass production any earlier than 1940 even with higher priority, though more limited engines would obviously need to be used for prototypes. (the Bramo 323 might even be favored there due to engine availability, at least for protoypes and possibly early production or preproduction models)I don't know about the fuel and oil but the JU 252 started with 1350hp engines. In 1938 The Jumo 211A as used in the He 111E was giving 1010hp for take off and 960hp at 4,920ft. With about 75% of the power available I doubt either performance or payload would be described as "sparkling"
I doubt the Ju 252 would have reached mass production any earlier than 1940 even with higher priority, though more limited engines would obviously need to be used for prototypes. (the Bramo 323 might even be favored there due to engine availability, at least for protoypes and possibly early production or preproduction models)
The 252 really seems more like a C-46 counterpart than anything, and (at least in basic layout, size, engine power, and passenger capacity) the Fw 206 seems much more in line with the DC-3. Given the design relation to the Fw 200 and the less advanced features compared to the 252, that might have been practical to get into service in numbers sooner as well. (in spite of its relatively late design start) That design never progressed beyond models and mock-ups before its cancellation, from what I've read, so a lot more left to speculation than the Ju 252.
That's because it started as a commercial aircraft for Lufthansa. If RLM had written specifications for a Jumo 211 powered military transport to replace Ju-52 during 1936 there's no reason it couldn't have been in production by 1940, replacing Ju-52 on the assembly line.