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Kind of depends on how much time you want to spend redesigning the whole thing. Trading three 1350hp engines that weigh around 13-1400lbs for two 22-2400hp engines that weigh around 2400lbs, shouldn't be too hard but then you done't get much, if any performance increase. You also have a bit of a problem if one quits.
Keeping 3 engines gives more performance but also increases the empty weight by well over 3000lbs. You aren't going to use Jumo 211 radiators to cool Ju 222 engines and you sure aren't going to use Jumo 211 propellers. If you use the extra power you are going to burn more fuel per mile/km. Payload is cut significantly. Now with the extra power you can certainly lift a bigger load but are the tires, landing gear, brakes up to it? Is the wing up to handling not only the extra weight but whatever extra speed you are using? and so on. Most passenger/cargo planes were built with much lower reserves of strength than Fighters or even bombers.
ANd do you really need a faster transport? If you go for the 66-7200hp installed power option is the plane now volume limited? Can lift more weight than the normal cargo items use up in volume?
Given the development timing of the Fw 200, and its wide (3 seat row) fuselage design, having a smaller twin engined counterpart using a similar, but shorter fuselage and smaller wing and tail (like the Fw 206 later did) would have made sense to develop in parallel with the larger trans-atlantic airliner. (and far more likely to actually be profitable ... or close to it -let alone strategically useful as a mass produced military transport)The DC3 flew and was in service by 1936, even the DC2 was an excellent aircraft. The best hope the Germans might have had was a He 111 with the fuselage physically widened out but using the same wings and empennage. similar to how the DC2 became the DC3. The great economies of production then make the transport viable and as the He 111 bomber was superseced production could shoft to the transport version. One then ends up with a conflict between He 111 bomber production and He 111 Transport production. The bomber would tend to win in the early part of the war. One might have to put radials on that He 111 Transport to spare Jumo 211 production.
Larger numbers of Ju 90s and Fw 200s built used as transports wouldn't have hurt either, but more cost effective 2 or 3 engine transports should have been the priority.Yes but who was thinking of resupplying whole divisions and even armies enough so that they would write a spec. There were some superbly thought out airliners planned (they often appear in Luft46 style aircraft) but they would have started production in the war years. Aint going to happen. Even the Ar 232 was effectively cancelled.
Any transport would need to be in production by 1937 else it comes into conflict with military priorities I would think.
Wait a second. How are you going to lose range with the 222's, didn't they have good fuel efficiency, wouldn't the removal of drag in the nose increase performance?
One reason the Jumo 222 was favoured over the DB604 and the BMW802 was its expected superbly high high speed cruise and cruise efficiency. This is of course of interest to a bomber which needs a sustained high speed cruise to minimise interception.