Maybe the stroke wasn't the limiting factor for the engine diameter, but the space required between cylinder barrels at their base.
For Allison's proposal (and Arsenal's version) of H24, they put the propeller shaft right in the center, so the distance from crankshaft to crankshaft was determined by the diameter of the reduction gears e.g. If reduction gears were 10" center to center on the V-12, the centerlines of the crankshafts of the H-24 were 20" apart. This allows using common intake manifolds, common heads, common cylinder block (Crankcase is unique and rather substantial). Which as I understood
tomo pauk 's original premise was desired for this what if - he's wanting to just fancy up the manufacturing machines to handle either I-4 or I-6 components based on what is being built that shift. A bit of PIA for the manufacturing engineer - you need to make the machine so it doesn't a. damage itself when the wrong component is selected, b. damage the component. A challenge but not that complex.
The Napier Sabre uses 4 double reduction shafts; this allows the crankshafts to be very close (with appropriate timing, they wouldn't even need to be stroke distance apart.) This allows a combined cylinder block and head - which saves weight and the combined head stiffens thing up...which might allow further weight reduction, but there are issues with cooling if both banks exhaust are using same ports, routing coolant around cylinder barrels and manufacturing is going to need unique machines for the unique parts.
So teh Rolls-Royce Merlin RM.17SM producing 2,600hp+ counts?
I was going to use the Allison V-1710-127 of 2,980hp as what prototypes are capable of. But again Germans didn't have materials (cobalt, nickel) to build the VDT. Like the "Speed Spitfire's" Merlin/early DB603, companies could mix up brews that would provide much better power for prototypes, but those concoctions weren't something that could be used in service engines.
Two stage superchargers need (demand?) intercoolers.
We have two conflicting problems. The more boost you use, the hotter the intake charge is and the more likely the intake charge is to detonate in the cylinders.
The higher octane fuel you have the more boost you can use before detonation.
If you want 1.42 Ata at 25,000ft you have to compress the air at 3.8 times the air pressure. If you want to higher or use more boost you need to compress the air more and the intake aid is going to be even hotter.
At 20,000ft if you want 1.42 you only have to compress the air 3.09 times.
I'm going to reference Callum's book too:
A two stage supercharger needs efficient compressors for each stage, otherwise it really isn't buying you much.
Now, it is easier to design a single stage compressor which just needs to be efficient in a narrow window of limited compression say just 2.0ata. Then design a 2nd stage to compress from 0 to 2 ata to reach your 4 ata at 25k' e.g. P&W and Allison.
The other part of the equation - the huge cylinders (>160mm bore/180mm stroke) are more susceptible to detonation.
There is also the problem of needing to crawl before walking/walking before running.
tomo pauk needs a V-12 running so all the work of selecting everything from supercharger to crankshafts (bearing sizes, finishes, etc) to heads to reduction gears production ready, before committing to the H-16 or he risks throwing everything away. What Junker's didn't know about pressurized cooling through '40, they didn't know. In a time warp scenario, yes, we could provide them with that; but this was just try an H-16 instead of coupled V-12s.
Having an OK working engine today is better then terrific engine after the war is over.