Stating that R-2180E was half of the R-4360 is probably simplification of matters? The rows will be stacked in different way, with second row rotated exactly by 1/14th of the circle vs. 1st row. That means a brand new crankcase and crankshaft. It will certainly feature a new supercharger, new valve gear, new way the baffles are designed, new air plumbing between difuser and cylinders, new reduction gear (that can be lighter due to lower loadings) etc. New ignition system. Probably a different vibration pattern?
It was unique all right, but not enough to make a lot of difference. There was no superchaging worth talking about from military point of view, and with developed R-2800, R-2600, Hercules making the post-war glut, the commercial success was modest. I don't think that we can say it was better than those established engines.
FWIW, the fact sheet for both the -A (pre-war Twin Hornet) and the -E engines (post-war Twin wasp):