There is a lot of "stuff" going on with the change from biplane to monoplane and things can rarely (if ever) reduced to a single sentence.
Lockheed was flying this thing in 1931.
Wing loading was about 14.9lb/sq/ft.
You could get rid of the upper wing but now you needed to make the wing strong enough to do without the bracing of the upper wing. (or lower if you made a high wing monoplane) and for light weight that meant a thick wing. Much thicker than most biplanes ever used.
Unbraced monoplanes go back to WW I.
Semi-braced?
WW I
Arguments about parasol and bracing aside even the D. VIII had low (lowish?) wing loading of 11.6lb/sq/ft.
Which with the thick airfoils used the above examples did not allow for large gains in speed. Worthwhile yes but not the gain the later monoplanes would get.
Please note that all 3 planes had some rather large contributors to drag
aside from the wing type/size/airfoil.
In the early 30s the engine makers were moving away from water to Prestone which allowed radiators to be smaller.
They were also designing better fairings for air cooled engines which much less drag.
The airframe makers were moving to retracting landing gear (or at least fairing it or streamlining it better).
They were putting brakes in landing wheels instead of a depending on skid plowing a trench in the ground to slow the airplane down on landing.
They were putting flaps and slats on wings to allow the wing to be configured for both high speed and high lift/drag for landings and take-off.
They had to get a number of things to work together to get the planes up to the high 200s and into the 300mph range.