With one plane and one bomb, very precise accuracy would be required. The technology did not exist in WW2, except possibly remote control TV guided weapons. None of other systems would have provided the accuracy. Rf guidance was susceptible to countermeasures, and the Brits were good at it. Inertial nav capability was no where near good enough. In the 70s INSs drifted at a mile an hour. If any beam system would have worked, they would have been used in Vietnam and many crew could have been saved, but, they weren't. The TV remote guided Bullpup was marginally effective, but not until TV guided and laser guided weapon became available did one bomb one hit became possible and even then spotter aircraft was needed. In the 1980s, the B-2 was tasked with very precise autonomous dumb bomb drops (yes even nuclear bombs sometimes need to be precisely delivered). In order to achieve this accuracy, a highly precise INS system actively updated by a stellar inertial system and a high resolution radar update capability was required. None of these systems existed prior to the 80s, much less WW2. The Germans were never going to have a precise V-1 system. Now if they had cancelled the He 177 and built another 9000 V-1s, this would certainly have shaken up Britain and occupied a lot of military defense. Still wouldh't have changed the war.