Expecting from the plane that was in service in late 1941/ early 1942 to compete, on level footing, with the almost post-war plane is hardly fair, though the P-38K and latest P-38Ls would've given any late war plane a good run for their money, even half a continent/ocean away. Not sure many others were capable to return the favor.
One could compare planes of '1946' - ones that were ready to be produced, but the end of war occured 1st. Hence, the Do-335 is in the league of DH Hornet, or Grumman F7F - exceptional engines mated to the airframes of modest size (the smallest that could accomodate the engines, while the complete plane offers great deal of usability).