Yes
On 8 July 1945 16 N1K1s of the Tsukuba Kokutai fought against 20 P-51Ds near Tokyo. The N1K1s claimed three P-51s shot down and two P-51s were lost after they were shot down near Hyakurigahara naval base
I have one for the N1K2 as well. On 12 April 1945 Yokosuka Kokutai N1K2s and 302nd Kokutai J2Ms as well as IJAAF force aircraft intercepted B-29s and P-51Ds over Tokyo. Famous ace Kaneyoshi Muto who was flying an N1K2 of the Yokosuka kokutai (probably with the tail code with the backwards "E" and 104) was credited with a P-51. His victim was probably the P-51 flown by Gordon A Christoe who was last seen being attacked by an enemy fighter.