Point is that just having a cheaper per aircraft cost may not be the best actual economy.
Just like the DC-3 was the first successful airliner. You could actually make money with it. Ticket prices and freight charges paid for the plane (loans), operating expenses (fuel, labor/maintenance, etc.) and had a bit of left over profit. Every airliner before that needed a government subsidy.
In the USA, mind. There were European airliners that could match the DC-3 in economy and usability, they just weren't operating in the same conditions. It's also worth noting that the success of the DC-3, while certainly growing before the outbreak of WW2, was nowhere near as appreciated until after the war and surplus military C-47s began equipping airlines around the world that it truly gained recognition for its qualities. Before WW2 there weren't many DC-3s operating outside the USA, certainly not compared to after the war. KLM was one of the few pre-war foreign DC-3 operators, receiving its first in 1936, but it had also been a DC-2 customer. The Soviet Union was one of the first countries to recognise its qualities, and that resulted in several Douglas-built examples making their way to the SU, and licence production.