You can disagree with my assessment but how about coming up with something to show how it is wrong.
Some of my opinion is based off comparing the normal Lancaster to the Lancastrian airliner.
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Which, despite running lighter than the Lancaster bomber, (53,000lbs mean weight vs 55,000lbs for the MK III Lancaster) was not 30mph faster despite the longer, better faired nose, the longer faired tail, and absence of H2S blisters (or any other kind) on the belly of the aircraft.
It was about 20mph faster at max weak mixture. Power levels are going to be very similar as the Merlin 24 in the Lancastrian, the Merlin 22, 32,38s in the Lancasters all ran at 2650rpm and 7lbs boost for max weak mixture. The Merlin 24 was allowed 18lbs boost due to a stronger clutch in the supercharger drive.
The Merlin 85 was rated at 2650rpm and 7lbs boost for max weak cruising in low gear and 2850rpm and 7lb in high gear. The Merlin 85 was a low altitude two stage engine. It was rated at 1580hp at 16,000ft in high gear (18lbs boost) The Merlin 24 was rated at 1510hp at 9250ft in high gear (18lbs of boost) so yes the Merlin 85 will give 7-8,000ft more ceiling.
The Lancastrian airliner was supposed to have a max speed of 310mph at 12,000ft. while weighing 53,000lbs.
Granted the Lanc Mk VI will be flying higher but getting it to 345mph is going to take an awful lot of doing.
BTW here is a report on the difference between standard conditions and tropical conditions as regards the Lancaster.
http://www.wwiiaircraftperformance.org/Lancaster/Lancaster_I_PD435_Performance.pdf
Make of it what you will but I think the 28,500 ceiling for the Lancaster MK VI is in serious jeopardy.
See part where the service ceiling of the Lancaster (with Merlin 24s) at 70,000lbs dropped from 20.100ft to 15,700ft and it took 61 minutes to reach the lower height vs 51 minutes to reach the higher altitude.
The Merlin 85s will improve things (ceiling especially, climb times not so much) as will running at a lighter weight as fuel is burned off but the the idea of getting a Lancaster VI to the same operating altitudes as a B-29 in tropical conditions seems to be an illusion.