Just to weigh in. .22mag in an awesome round especially from a pistol. It sounds like a cannon and the muzzle flash is 3ft in diameter. The Keltec PMR-30 .22WMR is a semiautomatic with a 30 round clip and a Pic-rail for laser or flashlight. FN's FIVE-seven is also a very nice handgun but the ammo is expensive and not easy to find.
Revolvers are simple, easy, and rarely jam BUT, in general only 6 rounds. Ruger's SP101 in .32mag is a very potent weapon and the .32mag is supposed to have the same impact as the .357. In addition you can shoot plain .32 and .32Long.
There is another thread on "Experience with Weapons" that covers this as well. Now as to "Home Defense", most any homebound situation is going to be an "across a room" confrontation with adrenaline pumping. I maintain that in that scenario a shotgun is hard to beat. While most insist on 12ga. my preference is Mossberg's SA-20 semi-auto in 20ga. The 20ga shell delivers the impact of 2 .44mag rounds without the danger of shooting through several walls. The gun is light, easy to maneuver, and has less recoil than the 12ga. ideal for "in the house".
Bobby, we depart on handguns. I love my Python in .357 and my "Custer Colt" SAA in the old .45Long. I personally find DA distracting and have never fired my Python in DA mode. Besides SA slows you down and makes you think and aim before shooting. The semi-autos promote the "spray and pray" policy