FLYBOYJ
"THE GREAT GAZOO"
Lockheed considered and studied putting Merlins in the P-38 at least three different times during the course of the war.
Compared to the competing V-1710 with its turbosuperchargers there was little, if any, performance improvement with the heavy Merlins.
However the significant issue was that the Merlins were much less fuel efficient and could not be fitted with a turbo, thereby considerably shortening the range of the P-38, one of the signature advantages of the Allison powered P-38.
I started a thread on this - THE MYSTICAL MERLIN POWERED P-38
I doubt 3 times, it was more like one time but it just festered until 1944. There was a lot more to consider than fuel efficiency. At the end of the day a Merlin powered P-38 would not have been the decision of Lockheed but the AAF.
It seems that Rolls Royce was going to attempt to put Merlins in a P-38 (see my post). Powers to be to a halt to any further development.