Lets see a mission plan instead of theoretical.
I've ready presented a rough outlinebut here it is again:
At start.
200IG internal fuel, 45IG ST, 2 x 50IG DTs,
50IG of internal fuel for TO, cruise climb to reach the coast at 30K ft.
Cruise for ~1.5 hrs at 300mpg at Max weak mixture = 100IG in DT's to reach rendezvous point.
Rejoin bombers with 150IG internal fuel and 45IG ST.
Expend 70-95IG covering bombers
Return to UK when fuel reached 130-100IG remaining.
Here's map of the Schweinfurt raid:
And these fuel numbers match up with Spitfire Data cards and seem tp present no problems with flying the mission.