Re-engining the He-100 for a different type of in-line should not be harder that re-engining the in-line-engined fighter into a radial-engined one,or vice versa.
On something like a P-36 to P-40 the engine mounts/bearers go to about the same attachment points
at the firewall/bulkhead/frame and the loads are transferred to the structure ( longerons, truss framework, whatever). The fuselage
covering/outer skin bears NO structural loads and is merely an aerodynamic covering for the engine ( and router of air for various needs).
The He 100 used something closer to this;
The outer covering is used (access hatches/doors aside) AS the engine mount. a more involved engineering problem.
It is possible (most anything is possible) but is it practical. Main stress attachments have to shift from the top/upper sides to the bottom/lower sides of the fuselage at the firewall/bulkhead.
Maybe install the whole power egg from the Avia 135, ditching the retractable raditor.
What "power egg"??
Just because a plane groups the radiator and oil cooler near the engine does not mean that the whole package (including cowl) comes off with just a few bolts/connections.
The retractable radiator on the HE 100 was sort of an auxiliary cooler. The bulk of the cooling was done by the wing surfaces, and the turtle deck/vertical fin/horizontal stabilizer surfaces for the oil cooling system.
I am not certain how much of the coolant was allowed to turn to steam in the He 100 system, if any. But the cooling requirements of the Hispano engine might be different than the DB engines used in the He 100.