Shortround6
Major General
The P-63 seems more like a case of just being a more advanced airframe overall. It doesn't seem that unrealistic that the engines used in the P-63 series could have been fitted to variants of the P-39 itself. (though maybe some complications due to added length or change in CoG).
only if the variant was 1.5 to 2 ft longer. P-63 also changed wing location.
Good enough to be a reasonable substitute for the Mustang had NA not developed that machine on their own, especially if the merlin engined P-63 project had gone though. (Mustang production started sooner and the USAAF didn't put in massive orders for the P-63, so it's hard to say how well they'd have coped with ramping up production compared to what NA managed historically)
P-63 still had miserable fuel capacity. 126-128US gallons internal.
US pilots might have continued to complain about the 37 mm cannon, but it doesn't seem unreasonable that 20 mm alternative mountings could have been substituted, or even just another .50 cal.
Dropping to a .50 through the prop and the P-39/P-63 loose their reason for being. A 5 machine gun fighter brings what to the table vs the existing 4 and 6 gun fighters?