One thing about the 109 that I think made it somewhat better to fly was the position of the pilot. I have read that the more prone position in the 109 (unlike Allied aircraft) allowed the pilot to survive 'g' forces better because the body/blood wasn't negatively affected as much as in other aircraft. The coffin canopy was another story........
It was also to do with the high knees sitting position, the British just experimented with amputating D.Baders legs. Joking of course but I did read that some of his contemporaries felt he had an advantage